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2.3.1.242

Accepted name:

Kdo₂-lipid IV_A palmitoleoyltransferase

Reaction:

a (9Z)-hexadec-9-enoyl-[acyl-carrier protein] + Kdo₂-lipid IV_A = (9Z)-hexadec-9-enoyl-Kdo₂-lipid IV_A + an [acyl-carrier protein]

Glossary:

Kdo = 3-deoxy-D-manno-oct-2-ulopyranosylonic acid
lipid IV_A = 2-deoxy-2-[(3R)-3-hydroxytetradecanamido]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-β-D-glucopyranosyl-(1→6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[(3R)-3-hydroxytetradecanamido]-α-D-glucopyranosyl phosphate
Kdo₂-lipid IV_A = α-Kdo-(2→4)-α-Kdo-(2→6)-lipid IV_A
(9Z)-hexadec-9-enoyl = palmitoleoyl
(9Z)-hexadec-9-enoyl-Kdo₂-lipid IV_A = α-Kdo-(2→4)-α-Kdo-(2→6)-2-deoxy-2-{(3R)-3-[(9Z)-hexadec-9-enoyl]tetradecanamido}-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-β-D-glucopyranosyl-(1→6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[(3R)-3-hydroxytetradecanamido]-α-D-glucopyranosyl phosphate

Other name(s):

LpxP; palmitoleoyl-acyl carrier protein-dependent acyltransferase; cold-induced palmitoleoyl transferase; palmitoleoyl-[acyl-carrier protein]:Kdo₂-lipid IV_A O-palmitoleoyltransferase; (Kdo)₂-lipid IV_A palmitoleoyltransferase; α-Kdo-(2→4)-α-(2→6)-lipid IV_A palmitoleoyltransferase

Systematic name:

(9Z)-hexadec-9-enoyl-[acyl-carrier protein]:Kdo₂-lipid IV_A O-palmitoleoyltransferase

Comments:

The enzyme, characterized from the bacterium Escherichia coli, is induced upon cold shock and is involved in the formation of a cold-adapted variant of the outer membrane glycolipid lipid A.

References:

1.	Carty, S.M., Sreekumar, K.R. and Raetz, C.R. Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein. J. Biol. Chem. 274 (1999) 9677–9685. [PMID: 10092655]
2.	Vorachek-Warren, M.K., Carty, S.M., Lin, S., Cotter, R.J. and Raetz, C.R. An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C. J. Biol. Chem. 277 (2002) 14186–14193. [PMID: 11830594]

[EC 2.3.1.242 created 2014]